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Prasad, K.
- Influence of Coenzyme Q10 on Phenothiazine Induced Extrapyramidal Symptoms in Rats
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Authors
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1 Department of Pharmacology, H.K.E Society's College of Pharmacy, Sedam Road, Gulbarga - 585105, Karnataka, IN
1 Department of Pharmacology, H.K.E Society's College of Pharmacy, Sedam Road, Gulbarga - 585105, Karnataka, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 2, No 3 (2010), Pagination: 248-251Abstract
Single dose and multiple dose influence of, Coenzyme Q10 in chlorpromazine induced catatonia was studied in adults albino rats of either sex. The study intended to find the role of antioxidants coenzyme Q10 in controlling extrapyramidal side effects. Phenothiazine derivatives produce catatonia as an unwanted side effect when used especially for prolonged periods of time in psychiatric disorders. The catatonia was induced in albino rats using chlorpromazine in the dose of 0.9mg/200g p.o. and the degree of catatonia was recorded.
Coenzyme Q10 was administered first followed by chlorpromazine after 30 minutes p.o in single dose studies. In multiple dose studies Coenzyme Q10 was administered for 8 days followed by the combination of Coenzyme Q10 and chlorpromazine on 9th day as described above and the degree of catatonia was scored. The study reveals that coenzyme Q10 produced statistically significant reduction of extrapyramidal symptoms in both single and multiple dose studies. Thus coenzyme Q10 has beneficial effects in controlling the toxicity symptoms of phenothiazines. Since, coenzyme Q10 is used safely in the form of food supplement it can be recommended in patients who are using phenothiazine derivatives for prolonged periods of time.
Keywords
Chlorpromazine, Catatonia, Coenzyme Q10, Extrapyramidal Symptoms.
References
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- Antiulcer Effect of Vitamin E with Lansoprazole in Treating Peptic Ulcer in Rats
Abstract Views :221 |
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Authors
Affiliations
1 Shri Vishnu College of Pharmacy, Bhimavaram-534202, A.P., IN
2 HKES College of Pharmacy, Department of Pharmacology, Sedam Road, Gulbarga-585105, Karnataka, IN
3 HKES College of Pharmacy, Department of Pharmacology, Gulbarga-585105, Karnataka, IN
1 Shri Vishnu College of Pharmacy, Bhimavaram-534202, A.P., IN
2 HKES College of Pharmacy, Department of Pharmacology, Sedam Road, Gulbarga-585105, Karnataka, IN
3 HKES College of Pharmacy, Department of Pharmacology, Gulbarga-585105, Karnataka, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 3, No 4 (2011), Pagination: 202-206Abstract
Peptic ulcer is a chronic and appalling disease. Today, it is dominant among the diseases that affect the world's population. The principal factors causing this disease are inadequate dietetic habits, prolonged use of non-steroidal anti-inflammatory drugs, stress and infection by Helicobacter pylori, in addition to other factors of genetic origin. The present study was designed to evaluate the combination effect of vitamin E with lansoprazole against pylorus ligation induced ulcer model in rats. The antiulcer effect of the combination of vitamin E 0.9mg/200g and lansoprazole 0.54mg/200g b.w. orally was compared with the reference standard lansoprazole 0.54mg/200 g b.w. orally. The ulcer index and other biochemical parameters like volume, pH, free acidity and total acidity of gastric juice were estimated. The ulcer index and other biochemical parameters like volume (***P < 0.001), free acidity (***P < 0.001), total acidity (***P < 0.001) and pH (**P < 0.01), of gastric juice showed reduction when compared to standard lansoprazole. The percentage protection of combination was 92.9% as compared to standard lansoprazole 82.8%. Thus the combination group was found to be synergistic in nature when compared to lansoprazole alone.Keywords
Antiulcer Activity, Vitamin E, Lansoprazole, Pylorus Ligation Model, Ulcer Index.References
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- Glossary of Callistemon lanceolatus D.C. – An Ornamental Plant with Marvellous Properties
Abstract Views :209 |
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Authors
Affiliations
1 Department of Pharmacology, National College of Pharmacy, Balraj Urs Road, Shivamogga (Dist)-577201, Karnataka, IN
1 Department of Pharmacology, National College of Pharmacy, Balraj Urs Road, Shivamogga (Dist)-577201, Karnataka, IN